Determinación del polimorfismo indel 19, en el gen de calaína - 10 en diabéticos y no diabéticos

Abstract

Abstract: Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia resulting from defects in secretion and / or insulin action. It has been shown that several genes involved in T2D, one of them is the CAPN10 gene that by positioning studies clonal in Mexico-American population showed that polymorphisms in this gene confer risk to develop T2D. Allele frequencies and genotype 19 Indel polymorphism in a pilot study in women with diabetics and nondiabetics Ecuadorians showed no significant differences when compared. Therefore expanded the sample size to confirm the results obtained Indel 19 polymorphism and its relationship with anthropometric and clinical characteristics. Have been analyzed 370 diabetics and nondiabetics individuals IESS Loja, for determining the Indel 19 and their anthropometric and clinical measurements, giving a genotype frequency in diabetics for 3R/3R 38.4%, 2R/2R 14.1% and 2R/3R of 47.6% with similar results for non-diabetics and showed no significant difference (p= 0.35). While the allele frequency in diabetics for the 2R allele was 37.8% and 3R was 62.2% with similar results for nondiabetics with significant difference (p= 0.94). The results of genotypes and alleles with anthropometric and clinical characteristics of diabetics and nondiabetics patients showed significant differences (p< 0.05) for fasting glucose, body mass index, waist circumference, systolic/diastolic blood pressure, total cholesterol, LDL cholesterol and creatinina.