Optimización y evaluación in vitro de un fitocosmético a partir del extracto etanólico de Piper ecuadorense Sodiro de la región sur del Ecuador.

Abstract

In this research, the extract extract of Piper ecuadorense (Matico) was studied as the main component of a phytocosmetics cream. For this purpose, preformulation and formulation studies were carried out using a factorial experimental design that allowed to find the appropriate excipients that do not influence the degradation or decrease of the therapeutic potential of the extract. The amount of active ingredient was also valued using UV-vis spectrophotometry. The results were submitted to statistical treatment using the program Minitab ® 18, which allowed to choose the most stable formula, in this case we chose a formula in which it excludes Alcohol Cetyl as a rheological agent because its presence Produces a decrease in the concentration of the extract, as well as in some cases flocculation. Finally the formula obtained consists of: Alcohol stearyl (Agent rheological), parabens (preservatives) and sodium citrate (PH regulator) providing a greater strength to the formula and thus guarantee the efficacy and safety of the antifungal cream.