Genes GSTM1, GSTT1 y GSTP1 y su importancia en alteraciones metabólicas

Abstract

Abstract:Glutathione S-transferases are metabolic enzymes, responsible for detoxification endogenous and exogenous products. Deletion polymorphisms in GSTM1 and GSTT1 (null alleles), together with the SNP Ile105Val of GSTP1, result in dysfunctional enzymes, with different enzymatic activities; which is related to alterations in the cellular oxidative state, and is considered a risk factor for the development of metabolic alterations. The objective of the present study was to evaluate the association of these polymorphisms and/or their haplotypes with metabolic alterations or biochemical risk factors Loja s population. 791 samples were analyzed, by multiplex PCR (GSTT1 and GSTM1) and PCR-RFLP (GSTP1). The results showed a frequency of 34 and 32% for null GSTM1 and null GSTT1, respectively, and the variant allele G of GSTP1, which was the most frequent with 62%. When evaluating the relationship of polymorphisms with different metabolic alterations, the G/G genotype from GSTP1 was related to metabolic syndrome (MS) and with high levels of triglycerides in men, likewise null GSTT1 to hypertension, and with a high systolic blood pressure (SBP) in men.